Natural Rights are certain states of being which man enjoys independently from other men. In Enlightenment thinking, Government alters the Rights of man for the benefit of society, which is held to be a greater good.
The founding fathers of the United States believed that the Government of Britain was overly restrictive of their natural rights; so they formed their own.
Natural Rights aren’t strictly defined, they often include things like:
The Right to exert your will as you would like (Liberty, self-determination).
The Right to have property.
The Right to not be killed. (Life)
The Right to establish government.
The right to self-determination is the one predominantly restricted by government; since Do what you Will can include taking the Rights of others.